Leading the way to BEAT Lupus!

BEAT LUPUS is a clinical trial testing the effectiveness and safety of a combination of two drugs to reduce Systemic Lupus Erythematosus (Lupus) disease activity.



About the Trial

Find out more about the trial and answer some common questions.


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Check Eligibility

Check the inclusion and exclusion criteria.


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Find a Hospital

Locate and contact your nearest participating hospital.


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The Chief Investigator



Professor

Michael Ehrenstein


Professor Michael Ehrenstein is a Consultant Rheumatologist at UCL Hospitals.




The development of new treatments for lupus has been frustratingly slow. It is hoped that this combination of two biologic therapies will improve the lives of patients.


In 2012 Professor Ehrenstein and his team found successive treatments with Rituximab led to temporary improvements for lupus patients. However this was often followed by ever worsening flares.

Studies on other patients revealed that BAFF increases after taking rituximab and is associated with disease flares. This trial will test whether Belimumab can be used to prevent flares in patients with SLE post Rituximab therapy.

The research teams at 16 participating NHS Hospitals within the UK will test the effectiveness of treating patients with both Belimumab, (Benlysta) an antibody that blocks the actions of the B cell growth factor BAFF, and Rituximab, a drug designed specifically to deplete B cells.


MORE ABOUT THE TRIALPARTICIPATING HOSPITALS


Our Funders


The BEAT Lupus trial is funded by Arthritis Research UK, GlaxoSmithKline, and UCLH Biomedical Research Centre. The trial is sponsored by the Comprehensive Clinical Trials Unit at UCL.



Contact us

Contact the Clinical Trial Manager or Data Manager for more information about the BEAT Lupus trial.


CLINICAL TRIAL MANAGER

Felicia Ikeji
020 7679 9506
f.ikeji@ucl.ac.uk
CTU.beatlupus@ucl.ac.uk



DATA MANAGER

Miriam Pollard
0207 907 4691
m.pollard@ucl.ac.uk
CTU.beatlupus@ucl.ac.uk



Trial Identifiers

EudraCT : 2015-005543-14
ISRCTN : ISRCTN47873003


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